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PhD Defense | Charlotte Segers | Investigating microbial therapies to combat gut microbiome dysbiosis during pelvic irradiation | UAntwerpen

10 janvier '22

Name: Charlotte Segers

Date: January 10, 2022 - 17h15 CET

This live event will be streamed via MS Teams

 

Investigating microbial therapies to combat gut microbiome dysbiosis during pelvic irradiation

This multi-disciplinary PhD work contributed to a deeper understanding of the pathogenesis of pelvic irradiation-induced mucositis and dysbiosis in a mouse model, and the role of potentially radioprotective food supplements Limnospira indica PCC 8005 and Lacticaseibacillus rhamnosus GG herein. We developed a mouse model  for pelvic irradiation in which intestinal mucositis was described to precede dysbiosis. Using our newly implemented in vivo irradiation-gut-microbiome platform, we could show that L. rhamnosus GG was capable of exerting radioprotection through immunomodulation as well as microbe-microbe interactions. This creates opportunities to further explore the promising potential of L. rhamnosus GG as a probiotic treatment strategy for pelvic irradiation-induced mucositis and dysbiosis. For this reason, our research opens new doors to improve patients’ quality of life suffering from pelvic radiotherapy-induced side effects.

Promotor:

  • Sarah Lebeer (UAntwerpen)

SCK CEN mentors:

  • Felice Mastroleo (SCK CEN)

  • Mieke Verslegers (SCK CEN)

 

Click here for a list of obtained PhD degrees.

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